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What Is Half Life Of A Drug. It measures the time it takes for a given amount of the substance to become reduced by half as a consequence of decay, and therefore, the emission of radiation. Half life = 0.693 x vd/ total body clearance.
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In the context of medication, it is used a couple of ways. Half life of a drug is directly proportional to the volume of the distribution and inversely proportional to the clearance. If we know the elimination time, we can easily evaluate how often the drug should be administered to maximize its effect and minimize its adverse reactions.
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Half life of a drug is directly proportional to the volume of the distribution and inversely proportional to the clearance. Half life of a drug is directly proportional to the volume of the distribution and inversely proportional to the clearance. Beta half life = tissue / elimination half life. It measures the time it takes for a given amount of the substance to become reduced by half as a consequence of decay, and therefore, the emission of radiation.